Furosemide is very useful of the renin-angiotensin-aldosterone system. With heart failure furosemide leads to a sharp decrease in heart before loading (by narrowing capacitive veins). This early vascular effect is prostaglandin poseredkovanym and requires adequate renal function with activation of the renin-angiotensin system and unharmed synthesis of prostaglandins. Patients correlation between the concentrations of unbound (free) furosemide in tubular organs (determined on the basis of the rate of excretion of furosemide in urine) and exercised natriyeuretychnym effect is expressed in the form syhmoyidnoyi curve with the lowest effective rate of excretion of furosemide, which is approximately 10 micro grams minute. Thus, continuous infusion of furosemide is more effective than repeated bolus injection. Moreover, in addition to a bolus dosage, there is no significant increase in effect. The effect of furosemide is reduced if there is an understated tubular secretion or binding of drug to albumin within the tubules. We are selling lasix online.